KMID : 0387420060170010059
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Korean Society of Oriental Neuropsychiatry 2006 Volume.17 No. 1 p.59 ~ p.78
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The Effects of ChongMyungTang(CMT) and SanSaChongMyungTang(SCMT) on the Alzheimer¡¯s Disease Model
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Ha Su-Young
Jung In-Chul Lee Sang-Ryong
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Abstract
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Objective:This research investigates the effect of the CMT and SCMT on Alzheimer¡¯s disease.
Methods:The effects of the CMT and SCMT on (1) amyloid precursor proteins(APP), acetylcholinesterase(AChE) mRNA of PC-12 cells treated with CT-105; (2) the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA; (5) the infarction area of the hippocampus in Alzheimer¡¯s disease mice induced with CT105 & ${\beta}A$ were investigated
Results:1. The CMT and SCMT suppressed the expression of APP, AChE mRNA in PC-12 cells treated with CT-105 2. The CMT and SCMT suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 3. For the CMT and SCMT group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer¡¯s disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency 4. The CMT and SCMT suppressed the over-expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA in the mice with Alzheimer¡¯s disease induced by ${\beta}A$. 5. The CMT and SCMT reduced the infarction area of hippocampus with Alzheimer¡¯s disease induced by ${\beta}A$.
Conclusion: These results suggest that the CMT and SCMT may be effective for the prevention and treatment of Alzheimer¡¯s disease. Investigation into the clinical use of the CMT and SCMT for Alzheimer¡¯s disease is suggested for future research.
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KEYWORD
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ChongMyungTang(CMT), SanSaChongMyungTang(SCMT), Alzheimer¡¯s Disease
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